Antidepressants have a role in clinical practice but they are grossly over-utilized. As a certified psychopharmacologist, practitioner of The Center for Whole Psychiatry + Brain Recovery (Functional Medicine and traditional psychiatry) and Clinical Professor of Psychiatry at Georgetown School of Medicine, I prescribe antidepressants, but only after a thorough multi-faceted evaluation of the patient. We […]
Vitamin B12 deficiency and its detection have been in the news lately from the New York Times and The Dr. Oz Show. B12 Deficiency Effects Widespread The effects of vitamin B12 deficiency are widespread. Vitamin B12 has a major influence on the function of neurons and also on the ability of the bone marrow to […]
Many people would be surprised that the immune system, the gastro-intestinal tract and stress interact, but that is what the most recent of a number of studies shows. In this study on mice, (Brain, Behavior, and Immunity Volume 25, Issue 3, March 2011, Pages 397-407. Researchers demonstrated that psychological stress causes almost immediate changes to the […]
I was wandering around the internet last night, looking for scholarly articles on something called ‘methylation pathways’, when I came across a very disturbing article on the potentially quite toxic interaction between nitrous oxide (NO2) and certain states of B12 deficiency. Before getting into the nitty gritty, bottom line, let me give you some background. […]
Your Biologic Clock Your Biologic Clock keeps our body rhythms and sleep –wake cycles in synch with the light-day cycle of the earth. It is located in the suprachiasmatic nucleus (SCN) in the hormone control center of the brain, the hypothalamus. When light enters the eye, it activates this part of the brain and reduces […]
Yes! Over the last 20 years, ample evidence has accumulated to prove that inflammation in the body causes changes in the brain that lead to depression, anxiety, sleep problems, and memory problems. Inflammation comes from the Latin ‘inflammare’ — to set on fire. Our brain is ‘on fire’ when it is inflamed, or when our […]
According to a new study discussed on Health.com about 2.4% of people around the world have had a diagnosis of bipolar disorder at some point in their lifetime, according to the first comprehensive international figures on the topic. The United States has the highest lifetime rate of bipolar disorder at 4.4%, and India the lowest, with […]
Nutrition, Neuronal Protection and Depression Neuronal protection (protection against cognitive decline) requires glutathione peroxidase (a crucial enzyme which requires selenium, cysteine, carotenoids, zinc, and vitamin E) is an important aspect of the treatment of mood disorders both because they tend to be recurrent over one’s life, and because they are associated with neuronal loss in specific parts […]
Nutrition, Methylation, and Depression Nutritional support for the methylation cycle is another area in which nutrition plays a critical role. The methylation cycle is essential for mental and physical health. It is critical to the metabolism of catecholamines in the synapse via an enzyme (COMT) as well as the synthesis of ‘depression-relevant’ compounds such as melatonin, myelin […]
Efficacy and Use of Medications in the Treatment of Depression It is becoming widely recognized that the current treatment of mood disorders (such as depression), while offering better outcomes than several decades ago, leave much room for improvement. The remission rate at the end of the first phase of the well-publicized STAR-D study (1) was […]
